HY251, a Novel Decahydrocyclopenta[a]indene Analog, Induces Apoptosis via tBid-Mediated Intrinsic Pathway in Human Ovarian Cancer PA-1 Cells
DC Field | Value | Language |
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dc.contributor.author | Suh, Hyewon | - |
dc.contributor.author | Ko-woon Choi | - |
dc.contributor.author | Myung Sic Kim | - |
dc.contributor.author | Jeong-Hyeon Kim | - |
dc.contributor.author | Sun-Young Noh | - |
dc.contributor.author | Sung, Moon-Hee | - |
dc.contributor.author | Lee, Chul-Hoon | - |
dc.date.accessioned | 2021-06-23T08:28:22Z | - |
dc.date.available | 2021-06-23T08:28:22Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/34350 | - |
dc.description.abstract | We previously isolated a novel compound, HY251, with the molecular structure of 3-propyl-2-vinyl-1,2,3,3a,3b,6,7,7a,8,8adecahydrocyclopenta[a]indene-3,3a,7a,8a-tetraol from the roots of Aralia continentalis. The current study was designed to evaluate the detailed molecular mechanisms underlying the apoptotic induction by HY251 in human ovarian cancer PA-1 cells. TUNEL assay and Western blot analyses revealed an appreciable apoptotic induction in PA-1 cells treated with 60 μM of HY251 for 24 h. This apoptotic induction was associated with caspase-8-dependent Bid cleavage, which in turn resulted in the formation of pro-apoptotic truncated Bid (tBid), and activation of caspase-9 and -3, as well as the cleavage of poly(ADPribose)polymerase (PARP). Moreover, we found that this death event was also associated with the significant upregulation and activation of the p53 tumor-suppressor protein through phosphorylation at Ser15. Therefore, we suggest that HY251 may be a potent cancer chemotherapeutic candidate for the treatment of ovarian cancer. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국미생물·생명공학회 | - |
dc.title | HY251, a Novel Decahydrocyclopenta[a]indene Analog, Induces Apoptosis via tBid-Mediated Intrinsic Pathway in Human Ovarian Cancer PA-1 Cells | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4014/jmb.1209.09022 | - |
dc.identifier.scopusid | 2-s2.0-84868030520 | - |
dc.identifier.wosid | 000311761600020 | - |
dc.identifier.bibliographicCitation | Journal of Microbiology and Biotechnology, v.22, no.11, pp 1591 - 1595 | - |
dc.citation.title | Journal of Microbiology and Biotechnology | - |
dc.citation.volume | 22 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1591 | - |
dc.citation.endPage | 1595 | - |
dc.identifier.kciid | ART001714907 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | ARALIA-CONTINENTALIS | - |
dc.subject.keywordPlus | CASPASE ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ARREST | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | Aralia continentalis | - |
dc.subject.keywordAuthor | apoptotic induction | - |
dc.subject.keywordAuthor | tBid | - |
dc.subject.keywordAuthor | cytochrome c | - |
dc.subject.keywordAuthor | PA-1 cells | - |
dc.identifier.url | https://www.jmb.or.kr/journal/view.html?volume=22&number=11&spage=1591 | - |
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