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Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods
- Authors
- Patra, Chitta Ranjan; Kim, Jong-Ho; Pramanik, Kallal; d'Uscio, Livius V.; Patra, Sujata; Pal, Krishnendu; Ramchandran, Ramani; Strano, Michael S.; Mukhopadhyay, Debabrata
- Issue Date
- Nov-2011
- Publisher
- American Chemical Society
- Keywords
- Europium hydroxide [Eu-III(OH)(3)] nanorods; reactive oxygen species; hydrogen peroxide (H2O2); single-walled carbon nanotubes; in vivo angiogenesis; zebrafish model
- Citation
- Nano Letters, v.11, no.11, pp.4932 - 4938
- Indexed
- SCIE
SCOPUS
- Journal Title
- Nano Letters
- Volume
- 11
- Number
- 11
- Start Page
- 4932
- End Page
- 4938
- ISSN
- 1530-6984
- Abstract
- The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O-2 center dot-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O-2 center dot- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (flila:EGFP) zebrafish embryos.
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Related Researcher
- Kim, Jong-Ho
- ERICA 공학대학 (ERICA 배터리소재화학공학과)