Detailed Information
Cited 0 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Structure tuning of pyrazolylpyrrole derivatives as ERK inhibitors utilizing dual tools; 3D-QSAR and side-chain hopping
- Authors
- Kim, Mi-hyun; Chung, Jae Yoon; Ryu, Jae-Sang; Hah, Jung-Mi
- Issue Date
- Aug-2011
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Pyrazolylpyrrole; Anticancer agent; ERK inhibitors; 3D-QSAR; Side-chain hopping
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.21, no.16, pp 4900 - 4904
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 21
- Number
- 16
- Start Page
- 4900
- End Page
- 4904
- ISSN
- 0960-894X
1464-3405
- Abstract
- The ERK pathway is a well-known therapeutic target of cancer treatment with great advantage of selectivity between normal cells and cancer cells, and the number of direct ERK kinase inhibitors is quite limited considering large number of available ERK structure from PDB. Therefore, we tried to combine 3D-QSAR with side-chain hopping in an attempt to produce novel structures as ERK inhibitors. The predictive models with q(2) value of 0.867, r(2) value of 0.991 in CoMFA and q(2) value of 0.628, r(2) value of 0.950 in CoMSIA were used to select effective compounds from new library generated from side-chain hopping by CombiGlide. (C) 2011 Elsevier Ltd. All rights reserved.
- Files in This Item
- Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Hah, Jung Mi
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)