Physicochemical stability, pharmacokinetic, and biodistribution evaluation of paclitaxel solid dispersion prepared using supercritical antisolvent process
- Authors
- Shanmugam, Srinivasan; Park, Jae-Hyun; Chi, Sang-Cheol; Yong, Chul Soon; Choi, Han-Gon; Woo, Jong Soo
- Issue Date
- Jun-2011
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Paclitaxel solid dispersion; supercritical antisolvent process; accelerated/stress stability; pharmacokinetics; organ distribution
- Citation
- DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v.37, no.6, pp.628 - 637
- Indexed
- SCIE
SCOPUS
- Journal Title
- DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Volume
- 37
- Number
- 6
- Start Page
- 628
- End Page
- 637
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/37409
- DOI
- 10.3109/03639045.2010.533682
- ISSN
- 0363-9045
- Abstract
- Aim: To investigate the physicochemical stability, pharmacokinetics (PK), and biodistribution of paclitaxel (PTX) from paclitaxel solid dispersion (PSD) prepared by supercritical antisolvent (SAS) process. Methods: Physicochemical stability was performed in accelerated (40 degrees C 70 +/- 5% RH) and stress (60 degrees C) storage conditions for a period of 6 months and 4 weeks, respectively. PK and biodistribution studies were performed in rats following i.v. administration of PTX equivalent to 6 and 12 mg/kg formulations. Results: Physical stability of PSD showed excellent stability with no recrystallization of the amorphous form. Chemical stability of PSD in terms of % PTX remaining was 98.2 +/- 0.6% at 6 months and 97.9 +/- 0.3% at 4 weeks of accelerated and stress conditions, respectively. The PK study showed a nonlinear increase in AUC with increasing dose, that is, 100% increase in dose (from 6 to 12 mg/kg) resulted in 405.90% increase in AUC. Unlike PK study, the organ distribution study of PTX from PSD showed linear relationship with dose escalation. The order of organ distribution of PTX from highest to lowest for both PSD and Taxol (R) was liver>kidney>lung>brain. Conclusions: This study demonstrated excellent physicochemical stability with insight information on the PK and biodistribution of PTX from PSD prepared by SAS process.
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