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Identification and Characterization of Small-Molecule Inducers of Fetal Hemoglobin
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Nam, Tae-gyu | - |
| dc.contributor.author | Lee, Jongkook | - |
| dc.contributor.author | Walker, John R. | - |
| dc.contributor.author | Brinker, Achim | - |
| dc.contributor.author | Cho, Charles Y. | - |
| dc.contributor.author | Schultz, Peter G. | - |
| dc.date.accessioned | 2021-06-23T11:01:48Z | - |
| dc.date.available | 2021-06-23T11:01:48Z | - |
| dc.date.created | 2021-01-21 | - |
| dc.date.issued | 2011-05 | - |
| dc.identifier.issn | 1860-7179 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/38055 | - |
| dc.description.abstract | Induction of γ-globin, a component of fetal hemoglobin (HbF, α2γ2), represents one therapeutic strategy to ameliorate the pathological symptoms of sickle cell disease. A high-throughput screen of a large chemical library identified a 2,6-diamino-substituted purine, TN1, which induces HbF more potently than hydroxyurea in KU812 and K562 leukemia cell lines. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | WILEY-BLACKWELL | - |
| dc.title | Identification and Characterization of Small-Molecule Inducers of Fetal Hemoglobin | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Nam, Tae-gyu | - |
| dc.identifier.doi | 10.1002/cmdc.201000505 | - |
| dc.identifier.scopusid | 2-s2.0-79955042519 | - |
| dc.identifier.wosid | 000289860900005 | - |
| dc.identifier.bibliographicCitation | CHEMMEDCHEM, v.6, no.5, pp.777 - 780 | - |
| dc.relation.isPartOf | CHEMMEDCHEM | - |
| dc.citation.title | CHEMMEDCHEM | - |
| dc.citation.volume | 6 | - |
| dc.citation.number | 5 | - |
| dc.citation.startPage | 777 | - |
| dc.citation.endPage | 780 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
| dc.subject.keywordPlus | SICKLE-CELL-DISEASE | - |
| dc.subject.keywordPlus | GAMMA-GLOBIN GENE | - |
| dc.subject.keywordPlus | ERYTHROID PROGENITORS | - |
| dc.subject.keywordPlus | IN-VITRO | - |
| dc.subject.keywordPlus | INDUCTION | - |
| dc.subject.keywordPlus | HYDROXYUREA | - |
| dc.subject.keywordPlus | EXPRESSION | - |
| dc.subject.keywordPlus | MECHANISM | - |
| dc.subject.keywordPlus | BCL11A | - |
| dc.subject.keywordPlus | BLOOD | - |
| dc.subject.keywordAuthor | fetal hemoglobin | - |
| dc.subject.keywordAuthor | high-throughput screening | - |
| dc.subject.keywordAuthor | sickle cell disease | - |
| dc.subject.keywordAuthor | STAT3 | - |
| dc.identifier.url | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201000505 | - |
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Related Researcher
- Nam, Tae gyu
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)