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Identification and Characterization of Small-Molecule Inducers of Fetal Hemoglobin
- Authors
- Nam, Tae-gyu; Lee, Jongkook; Walker, John R.; Brinker, Achim; Cho, Charles Y.; Schultz, Peter G.
- Issue Date
- May-2011
- Publisher
- WILEY-BLACKWELL
- Keywords
- fetal hemoglobin; high-throughput screening; sickle cell disease; STAT3
- Citation
- CHEMMEDCHEM, v.6, no.5, pp.777 - 780
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMMEDCHEM
- Volume
- 6
- Number
- 5
- Start Page
- 777
- End Page
- 780
- ISSN
- 1860-7179
- Abstract
- Induction of γ-globin, a component of fetal hemoglobin (HbF, α2γ2), represents one therapeutic strategy to ameliorate the pathological symptoms of sickle cell disease. A high-throughput screen of a large chemical library identified a 2,6-diamino-substituted purine, TN1, which induces HbF more potently than hydroxyurea in KU812 and K562 leukemia cell lines.
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Related Researcher
- Nam, Tae gyu
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)