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Regulation of the final stage of mitosis by components of the pre-replicative complex and a polo kinase
- Authors
- Yim, Hyungshin; Erikson, Raymond L.
- Issue Date
- May-2011
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- Plk1; Cdc6; DNA replication; mitotic exit; chromosomal segregation
- Citation
- CELL CYCLE, v.10, no.9, pp.1374 - 1377
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELL CYCLE
- Volume
- 10
- Number
- 9
- Start Page
- 1374
- End Page
- 1377
- ISSN
- 1538-4101
- Abstract
- The accurate division of duplicated DNA is essential for maintenance of genomic stability in proliferating eukaryotic cells. Errors in DNA replication and chromosomal segregation may lead to cell death or genomic mutations that lead to oncogenic properties. Thus, tight regulation of DNA replication and mitosis is essential for maintaining genomic integrity. Cell division cycle 6 (Cdc6) is an essential factor for initiating DNA replication. Recent work shows that phosphorylation of Cdc6 by polo-like kinase 1 (Plk1), one of the essential mitotic kinases, regulates mitotic exit mediated by Cdk1 and separase. Here we discuss how pre-replicative complex factors are connected with Plk1 and affect mitotic exit.
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Related Researcher
- Yim, Hyungshin
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)