Analysis of toxicity of tetrabutyltin: comparing with EDC chemicals
- Authors
- An, Yu Ri; Kim, Seung Jun; Park, Hye-Won; Yu, So Yeon; Han, Jeong; Oh, Jung-Hwa; Yoon, Seok-Joo; Hwang, Seung Yong
- Issue Date
- Mar-2011
- Publisher
- 대한독성 유전단백체 학회
- Keywords
- Tetrabutyltin; HazChem Human array; Toxicity; Endotoxic
- Citation
- Molecular & Cellular Toxicology, v.7, no.1, pp.95 - 101
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- Molecular & Cellular Toxicology
- Volume
- 7
- Number
- 1
- Start Page
- 95
- End Page
- 101
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/38196
- DOI
- 10.1007/s13273-011-0013-1
- ISSN
- 1738-642X
- Abstract
- Exposure to environmental chemicals has been implicated in a number of adverse health effects, including immunotoxic, neurotoxic, reproductive toxic effects, and, above all, cancers. In the present study, we investigated toxicity of three environmental chemicals-bisphenol A (BPA), nonylphenol (NP), and tetrabutyltin (TTBT) in a human breast cancer cell line by HazChem Human array. We then found toxicity markers of TTBT through comparison with BPA and NP. Fifty three genes were differentially expressed and seventeen genes showed similar expression patterns. Ontology analysis showed differential expression of genes related to aging and apoptosis and genes having similarities associated with pregnancy and insemination. In this paper, we revealed potential TTBT toxic markers and endotoxicity of TTBT. This study could be a foundation for additional studies of TIBT toxicity.
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