Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities
- Authors
- Nam, Tae-gyu; Ku, Jin-Mo; Rector, Christopher L.; Choi, Hoyoung; Porter, Ned A.; Jeong, Byeong-Seon
- Issue Date
- Sep-2011
- Publisher
- ROYAL SOC CHEMISTRY
- Keywords
- VITAMIN-E; BREAKING PYRIDINOL ANTIOXIDANTS; AUTOXIDATION; ANALOGS; BIOLOGICAL MOLECULES; REACTIVITY; ALPHA-TOCOPHEROL; 6-AMINO-3-PYRIDINOLS; RADICALS; PEROXIDATION
- Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY, v.9, no.24, pp.8475 - 8482
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC & BIOMOLECULAR CHEMISTRY
- Volume
- 9
- Number
- 24
- Start Page
- 8475
- End Page
- 8482
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39210
- DOI
- 10.1039/c1ob05144j
- ISSN
- 1477-0520
- Abstract
- A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants.
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