Expression of superoxide dismutase (SOD) genes from the copper-exposed polychaete, Neanthes succinea
- Authors
- Rhee, Jae-Sung; Won, Eun-Ji; Kim, Ryeo-Ok; Lee, Jehee; Shin, Kyung-Hoon; Lee, Jae-Seong
- Issue Date
- May-2011
- Publisher
- Pergamon Press Ltd.
- Keywords
- Polychaete; Neanthes succinea; Copper and zinc superoxide dismutase; Manganese superoxide dismutase; Oxidative stress; Copper
- Citation
- Marine Pollution Bulletin, v.63, no.5-12, pp.277 - 286
- Indexed
- SCIE
SCOPUS
- Journal Title
- Marine Pollution Bulletin
- Volume
- 63
- Number
- 5-12
- Start Page
- 277
- End Page
- 286
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39211
- DOI
- 10.1016/j.marpolbul.2011.04.023
- ISSN
- 0025-326X
- Abstract
- To evaluate the superoxide dismutase (SOD) genes as a potential indicator of environmental stress, we cloned and sequenced the full-length cDNA of a Cu/Zn-SOD and Mn-SOD genes from the marine polychaete, Neanthes succinea. Ns-Cu/Zn- and Mn-SOD expression was measured using quantitative real-time RT-PCR in response to the oxidative stress induced by copper in the form of CuCl2. Ns-Cu/Zn-SOD expression increased in a dose dependent manner but the increase of Mn-SOD expression was evident only at a high concentration of copper. Particularly, Ns-Mn-SOD dramatically increased in the 72 mu g/L CuCl2-exposed groups, indicating that both Ns-SOD genes were induced by copper exposure. These results suggest that Ns-Cu/Zn- and Ns-Mn-SOD would play important roles in the detoxification of cellular oxidative stresses in the polychaete, N. succinea. Furthermore, as part of field work, the marine polychaete, N. succinea Cu/Zn-SOD mRNA collected from the polluted area was accordingly upregulated in expression but not for NS-Mn-SOD. (C) 2011 Elsevier Ltd. All rights reserved.
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