Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Junsang | - |
dc.contributor.author | Nam, Bong Soo | - |
dc.contributor.author | Kim, Hwan | - |
dc.contributor.author | Oh, Chang-Hyun | - |
dc.contributor.author | Lee, So Ha | - |
dc.contributor.author | Cho, Seung Joo | - |
dc.contributor.author | Sim, Tae Bo | - |
dc.contributor.author | Hah, Jung-Mi | - |
dc.contributor.author | Kim, Dong Jin | - |
dc.contributor.author | Tae, Jinsung | - |
dc.contributor.author | Yoo, Kyung Ho | - |
dc.date.accessioned | 2021-06-23T12:39:57Z | - |
dc.date.available | 2021-06-23T12:39:57Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39464 | - |
dc.description.abstract | The synthesis of a novel series of aminoquinazoline derivatives 1a-r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC50 = 0.006 mu M) and good selectivity over HS27 fibroblast cell line. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hah, Jung-Mi | - |
dc.identifier.doi | 10.1016/j.bmcl.2010.08.010 | - |
dc.identifier.scopusid | 2-s2.0-77957592790 | - |
dc.identifier.wosid | 000281735600026 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.19, pp.5722 - 5725 | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 20 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 5722 | - |
dc.citation.endPage | 5725 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | RANDOMIZED PHASE-III | - |
dc.subject.keywordPlus | METASTATIC MELANOMA | - |
dc.subject.keywordPlus | MALIGNANT-MELANOMA | - |
dc.subject.keywordPlus | DACARBAZINE | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | INTERLEUKIN-2 | - |
dc.subject.keywordPlus | FOTEMUSTINE | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Aminoquinazolines | - |
dc.subject.keywordAuthor | Synthesis | - |
dc.subject.keywordAuthor | Antiproliferative activity | - |
dc.subject.keywordAuthor | A375 human melanoma cell line | - |
dc.subject.keywordAuthor | Selectivity | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0960894X10011200?via%3Dihub | - |
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