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Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line
- Authors
- Lee, Junsang; Nam, Bong Soo; Kim, Hwan; Oh, Chang-Hyun; Lee, So Ha; Cho, Seung Joo; Sim, Tae Bo; Hah, Jung-Mi; Kim, Dong Jin; Tae, Jinsung; Yoo, Kyung Ho
- Issue Date
- Oct-2010
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Aminoquinazolines; Synthesis; Antiproliferative activity; A375 human melanoma cell line; Selectivity
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.19, pp.5722 - 5725
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 20
- Number
- 19
- Start Page
- 5722
- End Page
- 5725
- ISSN
- 0960-894X
- Abstract
- The synthesis of a novel series of aminoquinazoline derivatives 1a-r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC50 = 0.006 mu M) and good selectivity over HS27 fibroblast cell line. (C) 2010 Elsevier Ltd. All rights reserved.
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Related Researcher
- Hah, Jung Mi
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)