Phospholipid meets all-trans-retinal: the making of RPE bisretinoids
DC Field | Value | Language |
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dc.contributor.author | Sparrow, Janet R. | - |
dc.contributor.author | Wu, Yalin | - |
dc.contributor.author | Kim, Chul Y. | - |
dc.contributor.author | Zhou, Jilin | - |
dc.date.accessioned | 2021-06-23T13:39:02Z | - |
dc.date.available | 2021-06-23T13:39:02Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2010-02 | - |
dc.identifier.issn | 0022-2275 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39999 | - |
dc.description.abstract | The lipid phase of the photoreceptor outer segment membrane is essential to the photon capturing and signaling functions of rhodopsin. Rearrangement of phospholipids in the bilayer accompanies the formation of the active intermediates of rhodopsin following photon absorption. Furthermore, evidence for the formation of a condensation product between the photolyzed chromophore all-trans-retinal and phosphatidylethanolamine indicates that phospholipid may also participate in the movement of the retinoid in the membrane. The downside of these interactions is the formation of bisretinoid-phosphatidylethanolamine compounds that accumulate in retinal pigment epithelial cells with age and that are particularly abundant in some retinal disorders. The propensity of these compounds to negatively impact on the cells has been linked to the pathogenesis of some retinal disorders including juvenile onset recessive Stargardt disease and age-related macular degeneration.-Sparrow, J. R., Y. Wu, C. Y. Kim, and J. Zhou. Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. J. Lipid Res. 2010. 51: 247-261. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Phospholipid meets all-trans-retinal: the making of RPE bisretinoids | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chul Y. | - |
dc.identifier.doi | 10.1194/jlr.R000687 | - |
dc.identifier.scopusid | 2-s2.0-77949503904 | - |
dc.identifier.wosid | 000273620000003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LIPID RESEARCH, v.51, no.2, pp.247 - 261 | - |
dc.relation.isPartOf | JOURNAL OF LIPID RESEARCH | - |
dc.citation.title | JOURNAL OF LIPID RESEARCH | - |
dc.citation.volume | 51 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 247 | - |
dc.citation.endPage | 261 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | PIGMENT EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | LIGHT-INDUCED DAMAGE | - |
dc.subject.keywordPlus | ROD OUTER SEGMENTS | - |
dc.subject.keywordPlus | LYSOSOMAL DEGRADATIVE FUNCTIONS | - |
dc.subject.keywordPlus | RECESSIVE STARGARDT-DISEASE | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTOR | - |
dc.subject.keywordPlus | ABC TRANSPORTER ABCA4 | - |
dc.subject.keywordPlus | FACTOR-H POLYMORPHISM | - |
dc.subject.keywordPlus | MACULAR DEGENERATION | - |
dc.subject.keywordPlus | BLUE-LIGHT | - |
dc.subject.keywordAuthor | bisretinoids | - |
dc.subject.keywordAuthor | photooxidation | - |
dc.subject.keywordAuthor | fluorescence | - |
dc.subject.keywordAuthor | lipofuscin | - |
dc.subject.keywordAuthor | retina | - |
dc.subject.keywordAuthor | light | - |
dc.subject.keywordAuthor | visible spectrum | - |
dc.subject.keywordAuthor | absorbance | - |
dc.subject.keywordAuthor | all-trans-retinal dimer | - |
dc.subject.keywordAuthor | retinal pigment epithelium | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0022227520305307?via%3Dihub | - |
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