Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Phospholipid meets all-trans-retinal: the making of RPE bisretinoidsopen access

Authors
Sparrow, Janet R.Wu, YalinKim, Chul Y.Zhou, Jilin
Issue Date
Feb-2010
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Keywords
bisretinoids; photooxidation; fluorescence; lipofuscin; retina; light; visible spectrum; absorbance; all-trans-retinal dimer; retinal pigment epithelium
Citation
JOURNAL OF LIPID RESEARCH, v.51, no.2, pp.247 - 261
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF LIPID RESEARCH
Volume
51
Number
2
Start Page
247
End Page
261
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/39999
DOI
10.1194/jlr.R000687
ISSN
0022-2275
Abstract
The lipid phase of the photoreceptor outer segment membrane is essential to the photon capturing and signaling functions of rhodopsin. Rearrangement of phospholipids in the bilayer accompanies the formation of the active intermediates of rhodopsin following photon absorption. Furthermore, evidence for the formation of a condensation product between the photolyzed chromophore all-trans-retinal and phosphatidylethanolamine indicates that phospholipid may also participate in the movement of the retinoid in the membrane. The downside of these interactions is the formation of bisretinoid-phosphatidylethanolamine compounds that accumulate in retinal pigment epithelial cells with age and that are particularly abundant in some retinal disorders. The propensity of these compounds to negatively impact on the cells has been linked to the pathogenesis of some retinal disorders including juvenile onset recessive Stargardt disease and age-related macular degeneration.-Sparrow, J. R., Y. Wu, C. Y. Kim, and J. Zhou. Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. J. Lipid Res. 2010. 51: 247-261.
Files in This Item
Go to Link
Appears in
Collections
COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Chul Young photo

Kim, Chul Young
COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)
Read more

Altmetrics

Total Views & Downloads

BROWSE