Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz
- Authors
- Choi, Song Hwa; Kim, Young Mi; Lee, Jung Min; Kim, Sang Geon
- Issue Date
- Feb-2010
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- AMPK; antioxidant effect; cell survival; mitochondrial protection; oxidized metabolites of oltipraz; Phase II enzyme
- Citation
- EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, v.6, no.2, pp.213 - 224
- Indexed
- SCIE
SCOPUS
- Journal Title
- EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
- Volume
- 6
- Number
- 2
- Start Page
- 213
- End Page
- 224
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/40000
- DOI
- 10.1517/17425250903427972
- ISSN
- 1742-5255
- Abstract
- Importance of the field. Comprehensive studies indicate that oltipraz exerts cancer chemopreventive effects. Oltipraz has other therapeutic potentials, which include anti-fibrotic effect, inhibition of insulin resistance, mitochondrial protection and cytoprotective effect against oxidative stress. Although antioxidant mechanisms may account for its cancer chemopreventive effect, details on the molecular mechanism still remain to be clarified. Areas covered in this review. Two major metabolic pathways of oltipraz include oxidative desulfuration of the thione to yield 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiol-3-one and molecular rearrangement to 7-methyl-6,8-bis (methylthio)H-pyrrolo[1,2-a]pyrazine. In addition to the diverse pharmacological effects of oltipraz, the oxidized metabolites may have distinct biological effects on cell survival. The AMP-activated protein kinase pathway has been recognized as a key cascade for mitochondrial protection and cell survival events, which can be activated by the oxidized metabolites of oltipraz. What the reader will gain: in this review, the metabolic activation of oltipraz and the role of the cell signaling pathways in regulating the expression of Phase II genes and antioxidant activity are discussed with particular reference to their effects on mitochondrial protection and cell survival. Take home message: In terms of therapeutic potential, the findings reviewed here demonstrate a therapeutic potential for oxidized metabolite of oltipraz and offer comparison of antioxidant capacity between metabolites and parent compound.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/40000)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.