Preparation and Investigation of Vitamin B-6-Derived Aminopyridinol Antioxidants
- Authors
- Serwa, Remigiusz; Nam, Tae-gyu; Valgimigli, Luca; Culbertson, Sean; Rector, Christopher L.; Jeong, Byeong-Seon; Pratt, Derek A.; Porter, Ned A.
- Issue Date
- Oct-2010
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- antioxidants; lipid peroxidation; pyridinols; radical scavengers; radicals
- Citation
- CHEMISTRY-A EUROPEAN JOURNAL, v.16, no.47, pp.14106 - 14114
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMISTRY-A EUROPEAN JOURNAL
- Volume
- 16
- Number
- 47
- Start Page
- 14106
- End Page
- 14114
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/40519
- DOI
- 10.1002/chem.201001382
- ISSN
- 0947-6539
- Abstract
- 3-Pyridinols bearing amine substitution para to the hydroxylic moiety have previously been shown to inhibit lipid peroxidation more effectively than typical phenolic antioxidants, for example, alpha-tocopherol. We report here high-yielding, large-scale syntheses of mono- and bicyclic amino-pyridinols from pyridoxine hydrochloride (i.e., vitamin B6). This approach provides straightforward, scaleable access to novel, potent, molecular scaffolds whose antioxidant properties have been investigated in homogeneous solutions and in liposomal vesicles. These molecular aggregates mimic cell membranes that are the targets of oxidative damage in vivo.
- Files in This Item
-
Go to Link
- Appears in
Collections - COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/40519)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.