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A Luciferase/Single-Walled Carbon Nanotube Conjugate for Near-Infrared Fluorescent Detection of Cellular ATP
- Authors
- Kim, Jong-Ho; Ahn, Jin-Ho; Barone, Paul W.; Jin, Hong; Zhang, Jingqing; Heller, Daniel A.; Strano, Michael S.
- Issue Date
- Feb-2010
- Publisher
- John Wiley & Sons Ltd.
- Keywords
- ATP; biosensors; nanotechnology; nanotubes; near-infrared fluorescence
- Citation
- Angewandte Chemie - International Edition, v.49, no.8, pp.1456 - 1459
- Indexed
- SCIE
SCOPUS
- Journal Title
- Angewandte Chemie - International Edition
- Volume
- 49
- Number
- 8
- Start Page
- 1456
- End Page
- 1459
- ISSN
- 1433-7851
- Abstract
- Take the tube: The title conjugate provides spatiotemporal information of ATP in living cells by a two-step fluorescence quenching mechanism. OxyLrin, which is generated enzymatically in the reaction between ATP and D-luciferin (Lrin), is adsorbed onto the nanotubes and quenches their fluorescence (see picture). The sensor is highly selective toward ATP.
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Related Researcher
- Kim, Jong-Ho
- ERICA 공학대학 (DEPARTMENT OF MATERIALS SCIENCE AND CHEMICAL ENGINEERING)