Validation of 99mTc-labeled “4+1” fatty acids for myocardial metabolism and flow imaging: Part 1: myocardial extraction and biodistribution
DC Field | Value | Language |
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dc.contributor.author | Mirtschink, Peter | - |
dc.contributor.author | Stehr, Sebastian N. | - |
dc.contributor.author | Walther, Martin | - |
dc.contributor.author | Pietzsch, Jens | - |
dc.contributor.author | Bergmann, Ralf | - |
dc.contributor.author | Pietzsch, Hans-Juergen | - |
dc.contributor.author | Weichsel, Johannes | - |
dc.contributor.author | Pexa, Annette | - |
dc.contributor.author | Dieterich, Peter | - |
dc.contributor.author | Wunderlich, Gerd | - |
dc.contributor.author | Binas, Bert | - |
dc.contributor.author | Kropp, Joachim | - |
dc.contributor.author | Deussen, Andreas | - |
dc.date.accessioned | 2021-06-23T15:02:36Z | - |
dc.date.available | 2021-06-23T15:02:36Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.issn | 0969-8051 | - |
dc.identifier.issn | 1872-9614 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/40843 | - |
dc.description.abstract | Introduction: C-13, F-18 and I-123 fatty acids (FA) are used for myocardial imaging. Recently, our group showed that [Tc-99m]-labeled "4+1" FA are extracted into the rat and guinea pig myocardium. The present study evaluates determinants of myocardial uptake and whole body biodistribution of these FA derivatives. Methods: Studies were performed with isolated perfused hearts of Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with a FAT/CD36 deficiency, as well as with heart type FA binding protein knockout mice (H-FABP)(-/-) and H-FABP(+/+). Eight 4+1-Tc-99m-FA were applied for 3 min followed by 1-min washout. A mathematical model was used to analyze FA dynamics and binding to proteins. Whole-body distribution was studied in rats with and without Tween 80. In vitro fractionation studies with [Tc-99m]-FA assessed red blood cell uptake as well as association with plasma lipoproteins very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Results: Myocardial extraction was 19.0-33.0% of the infused dose in isolated WKY and 15.2-26.4% in SHR hearts. However, H-FABP(-/-) showed a marked reduction of tracer extraction [2.8+/-0.6%ID (percent injected dose) vs. 17+/-2%ID P<001]. Uptake in red blood cells (<1.2% ID) and incorporation into lipoproteins were negligible. Incubation of Tc-99m-FA with albumin reduced ventricular extraction (P<.001) into the range of established iodinated FA tracers. polyoxyethylene(20) sorbitan monooleate improved the heart-to-liver ratio in the biodistribution studies. Conclusions: Myocardial uptake of [Tc-99m]-FA 4+1 derivatives is dependent on H-FABP. These substances may therefore provide a new tool to specifically assess regional myocardial changes of H-FABP. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Validation of 99mTc-labeled “4+1” fatty acids for myocardial metabolism and flow imaging: Part 1: myocardial extraction and biodistribution | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.nucmedbio.2009.06.009 | - |
dc.identifier.scopusid | 2-s2.0-69249166078 | - |
dc.identifier.wosid | 000269852700014 | - |
dc.identifier.bibliographicCitation | Nuclear Medicine and Biology, v.36, no.7, pp 833 - 843 | - |
dc.citation.title | Nuclear Medicine and Biology | - |
dc.citation.volume | 36 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 833 | - |
dc.citation.endPage | 843 | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | BINDING PROTEIN GENE | - |
dc.subject.keywordPlus | EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | GLUCOSE-METABOLISM | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | LIPOPROTEINS | - |
dc.subject.keywordPlus | INFARCTION | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | KINETICS | - |
dc.subject.keywordAuthor | Technetium fatty acids | - |
dc.subject.keywordAuthor | isolated heart | - |
dc.subject.keywordAuthor | H-FABP | - |
dc.subject.keywordAuthor | CD36 | - |
dc.subject.keywordAuthor | myocardial imaging | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0969805109001607?via%3Dihub | - |
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