Subconjunctivally injected, liposome-encapsulated streptokinase enhances the absorption rate of subconjunctival hemorrhages in rabbits
DC Field | Value | Language |
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dc.contributor.author | Baek, Seung-Hee | - |
dc.contributor.author | Park, Sung Jin | - |
dc.contributor.author | Jin, Su-Eon | - |
dc.contributor.author | Kim, Jin-Ki | - |
dc.contributor.author | Kim, Chong-Kook | - |
dc.contributor.author | Hwang, Jeong-Min | - |
dc.date.accessioned | 2021-06-23T15:06:19Z | - |
dc.date.available | 2021-06-23T15:06:19Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 0939-6411 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/41007 | - |
dc.description.abstract | Liposome-encapsulated streptokinase (SK) was prepared with distearoylphosphatidylethanolamine-N[methoxy(polyethyleneglycol)-2000] (DSPE-PEG(2000)). In vitro release assay demonstrated over 81% of SK was released from liposomes at 48 h, and the effect of its subconjunctival injection on the absorption Fate of induced subconjunctival hemorrhage (SH) in rabbits was evaluated. After 8 h of SH induction, eyes were randomly assigned to one of four subconjunctival injection groups (10 eyes each): group A: the free form of SK (1000 IU/mL.); group B: liposome-encapsulated SK (1000 IU/mL): group C: 0.1 mL of liposomes; and group D: no injection. SHs were photographed at 8, 24, 48, 72, and 120 h after SH induction and their sizes were compared. Size decrease of the SH was faster in groups A and B than in groups C and D. Group B displayed significantly different absorption rates than group A at 24 and 48 h and with groups C and D at 24, 48, and 72 h, with the shortest mean elapsed time among all groups. The ocular absorption of SK was lower after the injection of the liposome-encapsulated SK than the free form. These results demonstrated that subconjunctival injection of liposome-encapsulated SK enhances the rate of SH absorption, especially in the early phases. (C) 2009 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Subconjunctivally injected, liposome-encapsulated streptokinase enhances the absorption rate of subconjunctival hemorrhages in rabbits | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Ki | - |
dc.identifier.doi | 10.1016/j.ejpb.2009.03.010 | - |
dc.identifier.scopusid | 2-s2.0-67449161557 | - |
dc.identifier.wosid | 000268119300009 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v.72, no.3, pp.546 - 551 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | - |
dc.citation.title | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | - |
dc.citation.volume | 72 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 546 | - |
dc.citation.endPage | 551 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ANTISTREPTOKINASE TITERS | - |
dc.subject.keywordPlus | ANTIBODY-TITERS | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Streptokinase | - |
dc.subject.keywordAuthor | PEG-containing liposome | - |
dc.subject.keywordAuthor | Liposome-encapsulated streptokinase | - |
dc.subject.keywordAuthor | Subconjunctival hemorrhage | - |
dc.subject.keywordAuthor | Subconjunctival injection | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S093964110900109X?via%3Dihub | - |
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