Subconjunctivally injected, liposome-encapsulated streptokinase enhances the absorption rate of subconjunctival hemorrhages in rabbits
- Authors
- Baek, Seung-Hee; Park, Sung Jin; Jin, Su-Eon; Kim, Jin-Ki; Kim, Chong-Kook; Hwang, Jeong-Min
- Issue Date
- Aug-2009
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Streptokinase; PEG-containing liposome; Liposome-encapsulated streptokinase; Subconjunctival hemorrhage; Subconjunctival injection
- Citation
- EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v.72, no.3, pp.546 - 551
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Volume
- 72
- Number
- 3
- Start Page
- 546
- End Page
- 551
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/41007
- DOI
- 10.1016/j.ejpb.2009.03.010
- ISSN
- 0939-6411
- Abstract
- Liposome-encapsulated streptokinase (SK) was prepared with distearoylphosphatidylethanolamine-N[methoxy(polyethyleneglycol)-2000] (DSPE-PEG(2000)). In vitro release assay demonstrated over 81% of SK was released from liposomes at 48 h, and the effect of its subconjunctival injection on the absorption Fate of induced subconjunctival hemorrhage (SH) in rabbits was evaluated. After 8 h of SH induction, eyes were randomly assigned to one of four subconjunctival injection groups (10 eyes each): group A: the free form of SK (1000 IU/mL.); group B: liposome-encapsulated SK (1000 IU/mL): group C: 0.1 mL of liposomes; and group D: no injection. SHs were photographed at 8, 24, 48, 72, and 120 h after SH induction and their sizes were compared. Size decrease of the SH was faster in groups A and B than in groups C and D. Group B displayed significantly different absorption rates than group A at 24 and 48 h and with groups C and D at 24, 48, and 72 h, with the shortest mean elapsed time among all groups. The ocular absorption of SK was lower after the injection of the liposome-encapsulated SK than the free form. These results demonstrated that subconjunctival injection of liposome-encapsulated SK enhances the rate of SH absorption, especially in the early phases. (C) 2009 Elsevier B.V. All rights reserved.
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