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Aminoquinoline derivatives with antiproliferative activity against melanoma cell line
- Authors
- Nam, Bong Soo; Kim, Hwan; Oh, Chang-Hyun; Lee, So Ha; Cho, Seung Joo; Sim, Tae Bo; Hah, Jung-Mi; Kim, Dong Jin; Choi, Jung Hoon; Yoo, Kyung Ho
- Issue Date
- Jul-2009
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Aminoquinolines; Antiproliferative activity; Melanoma cell line; Fibroblast cell line; Selectivity
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.13, pp.3517 - 3520
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 19
- Number
- 13
- Start Page
- 3517
- End Page
- 3520
- ISSN
- 0960-894X
- Abstract
- The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 mu M, respectively) and excellent selectivity against melanoma and fibroblast cell lines. (C) 2009 Elsevier Ltd. All rights reserved.
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Related Researcher
- Hah, Jung Mi
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)