Self-Assembling Peptide Amphiphile-Based Nanofiber Gel for Bioresponsive Cisplatin Delivery
- Authors
- Kim, Jin-Ki; Anderson, Joel; Jun, Ho-Wook; Repka, Michael A.; Jo, Seongbong
- Issue Date
- May-2009
- Publisher
- AMER CHEMICAL SOC
- Keywords
- Cisplatin; matrix metalloproteinase-2; nanofiber; peptide amphiphile; targeted drug delivery
- Citation
- MOLECULAR PHARMACEUTICS, v.6, no.3, pp.978 - 985
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR PHARMACEUTICS
- Volume
- 6
- Number
- 3
- Start Page
- 978
- End Page
- 985
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/41263
- DOI
- 10.1021/mp900009n
- ISSN
- 1543-8384
- Abstract
- The aim of this study is to develop a bioresponsive cisplatin (CDDP) delivery system with a self-assembling peptide amphiphile (PA) comprising a cell-adhesive matrix metalloproteinase-2 (MMP-2)-sensitive GTAGLIGQRGDS and a fatty acid. A biomimetic CDDP-PA gel was spontaneously formed upon incubating a mixture of CDDP and the PA for 5 h at 37 degrees C. CDDP-PA gel formation was confirmed by rheological analysis. The structure of self-assembled CDDP-PA nanofibers inside the gel was determined by transmission electron microscopy (TEM). Bioresponsive drug release from the biomimetic gel was demonstrated by in vitro MMP-2-triggered CDDP release. The MMP-2-sensitive CDDP release was dependent on the enzyme concentration in the medium. Enzymatic degradation of the CDDP-PA gel was confirmed by TEM images of the gel degraded in an MMP-2 containing medium. The MMP-2-triggered CDDP release as well as the presentation of RGDS in the gel would potentially provide a spatially and temporally controlled delivery system for targeted anticancer drug delivery.
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