Sensitive detection of DMSO/DMF in water, human urine and blood plasma using novel 1,8-naphthalimide-based amphiphilic spectroscopic probes
- Authors
- Kumar, Ashwani; Hur, Won; Seong, Gi Hun; Chae, Pil Seok
- Issue Date
- May-2021
- Publisher
- ELSEVIER SCI LTD
- Keywords
- DMSO; DMF detection; Fluorescence quenching; Naked eye detection
- Citation
- DYES AND PIGMENTS, v.189, pp 1 - 12
- Pages
- 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- DYES AND PIGMENTS
- Volume
- 189
- Start Page
- 1
- End Page
- 12
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/413
- DOI
- 10.1016/j.dyepig.2021.109240
- ISSN
- 0143-7208
1873-3743
- Abstract
- Dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) are industrial toxins that need to be sensed. We synthesized 1,8-naphthalimide-m-benzenesulfonamide (NBS)-bearing probes (1?5) with different pendant chains for sensitive detection of DMSO and DMF. These probes exhibited aggregation-induced emission enhancement with increasing water concentration in ethanol. Among these, monopod probes with a single NBS unit (1?4) selectively showed large fluorescence quenching upon addition of DMSO/DMF in water. Based on this result, we prepared two water-soluble probes (8 and 9) bearing the NBS unit. These probes displayed enhanced sensitivity in detecting DMSO/DMF in water compared to probe 1, showing an extraordinary low LOD of 0.0025% for DMSO and DMF detection in water. Probe 9 was similarly effective at sensitively sensing DMSO/DMF when tap or lake water was used as the medium, and the LOD of this probe was 0.05% when biological fluids such as diluted human urine and blood plasma were used instead of water. According to DLS, FE-SEM and zeta potential studies as well as DFT calculations, disaggregation of probe aggregates and electron transfer from the photoexcited probe to DMSO/DMF are likely both responsible for the high selectivity and sensitivity of this probe in detecting the organic solvents containing a sulfoxide/amide group.
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