Simultaneous Determination of Phenolic Acids and Phthalide Compounds by Liquid Chromatography for Quality Assessment of Rhizoma Cnidii
DC Field | Value | Language |
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dc.contributor.author | Islam, M. Nurul | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Sung, Chung-Ki | - |
dc.contributor.author | Dong, Mi-sook | - |
dc.contributor.author | Park, Young In | - |
dc.contributor.author | Jin, Changbae | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.date.accessioned | 2021-06-23T15:42:00Z | - |
dc.date.available | 2021-06-23T15:42:00Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2009-03 | - |
dc.identifier.issn | 1060-3271 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/41376 | - |
dc.description.abstract | This paper describes a simple, rapid, and validated reversed-phase high-performance liquid chromatographic method developed for the determination of 4 major bioactive constituents, namely, chlorogenic acid, ferulic acid, senkyunolide A, and Z-ligustilide in Rhizoma Cnidii extract. A Capcell Pak C-18 chromatographic column (150 x 4.6 mm, 3 mu m) was used with mobile phases consisting of 0.1% formic acid, acetonitrile, and methanol at a flow rate of 0.8 mL/min and UV detection at 285 nm. Comprehensive validation of the method included evaluation of linearity, repeatability, recovery, and stability. Excellent linear behavior (r(2) >0.99) was observed over the concentration range of 2-100 mu g/mL for the compounds under investigation. Repeatability and accuracy were evaluated by intra- and interday assays; the relative standard deviation (RSD) values were <= 5.37% and accuracies ranged from 97.1 to 104.9%. Recoveries of the compounds ranged from 94.2 to 104.2% with RSD values of <= 9.50%. The developed method was successfully applied to the analysis of ethanolic extracts of Rhizoma Cnidii samples. As a result, the concentrations of chlorogenic acid, ferulic acid, Z-ligustilide, and senkyunolide A were determined to be 0.84-5.35, 0.45-1.65, 0.74-4.39, and 0.32-1.14 mg/g herb, respectively. Thus, the developed method was found to be accurate and reproducible and is considered suitable for the qualitative and quantitative analysis of Rhizoma Cnidii for bioactive compounds. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AOAC International | - |
dc.title | Simultaneous Determination of Phenolic Acids and Phthalide Compounds by Liquid Chromatography for Quality Assessment of Rhizoma Cnidii | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1093/jaoac/92.2.375 | - |
dc.identifier.scopusid | 2-s2.0-69249174331 | - |
dc.identifier.wosid | 000265309100003 | - |
dc.identifier.bibliographicCitation | Journal of AOAC International, v.92, no.2, pp.375 - 381 | - |
dc.relation.isPartOf | Journal of AOAC International | - |
dc.citation.title | Journal of AOAC International | - |
dc.citation.volume | 92 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 375 | - |
dc.citation.endPage | 381 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | UMBELLIFEROUS MEDICINAL-PLANTS | - |
dc.subject.keywordPlus | LIGUSTICUM-CHUANXIONG | - |
dc.subject.keywordPlus | OFFICINALE MAKINO | - |
dc.subject.keywordPlus | ANGELICA | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | SENKYUNOLIDE | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | FINGERPRINTS | - |
dc.subject.keywordPlus | COMPONENTS | - |
dc.subject.keywordPlus | CULTURES | - |
dc.identifier.url | https://academic.oup.com/jaoac/article/92/2/375/5655807?login=true | - |
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