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A small molecule inhibitor of alpha 4 integrin-dependent cell migration
- Authors
- Lee, Jongkook; Hong, Jiyong; Nam, Tae-Gyu; Peters, Eric C.; Orth, Anthony P.; Geierstanger, Bernhard H.; Goldfinger, Lawrence E.; Ginsberg, Mark H.; Cho, Charles Y.; Schultz, Peter G.
- Issue Date
- Feb-2009
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- COTTON-TOP TAMARIN; GAMMA-PARVIN; ANTAGONISTS; ANTIBODY; KINASE; LIBRARIES; COLITIS; BINDING
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY, v.17, no.3, pp 977 - 980
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY
- Volume
- 17
- Number
- 3
- Start Page
- 977
- End Page
- 980
- ISSN
- 0968-0896
1464-3391
- Abstract
- A small molecule inhibitor of alpha 4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha 4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases. (C) 2008 Elsevier Ltd. All rights reserved.
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Related Researcher
- Nam, Tae gyu
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)