A Novel Clotrimazole-loaded Suppository with Effective Anti-tumor Activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xuan, Jing Ji | - |
dc.contributor.author | Kim, Jong Tae | - |
dc.contributor.author | Oh, Dong Hoon | - |
dc.contributor.author | Lee, Won Seok | - |
dc.contributor.author | Lee, Jong Sook | - |
dc.contributor.author | Rhee, Jong Dal | - |
dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Woo, Jong Soo | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.date.accessioned | 2021-06-23T17:04:35Z | - |
dc.date.available | 2021-06-23T17:04:35Z | - |
dc.date.created | 2021-02-18 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.issn | 2093-5552 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42153 | - |
dc.description.abstract | To develop a poloxamer-based solid suppository with poloxamer and polyethylene glycol mixtures, the melting point of various formulations composed of P 188 and propylene glycol were investigated. The dissolution and antitumor activity of clotrimazole delivered by the poloxamer-based suppository were performed. The poloxamer mixtures composed of P 188 and propylene glycol were homogeneous phases. P 188 greatly affected the melting point of poloxamer mixtures. In particular, the poloxamer mixture [P 188/propylene glycol(70/30%)] with the melting point of about was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, the ratio of P 188/propylene glycol greatly affected the dissolution rates of clotrimazole from poloxamer-based suppository. It gave the more effective anti-tumor activity than conventional PEG-based suppository due to fast dissolution. Thus, the clotrimazole-Ioaded poloxamer-based solid suppository was an effective rectal dosage form with anti-tumor activity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국약제학회 | - |
dc.title | A Novel Clotrimazole-loaded Suppository with Effective Anti-tumor Activity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.bibliographicCitation | 약제학회지, v.38, no.5, pp.289 - 293 | - |
dc.relation.isPartOf | 약제학회지 | - |
dc.citation.title | 약제학회지 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 289 | - |
dc.citation.endPage | 293 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001286659 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Clotrimazole | - |
dc.subject.keywordAuthor | Suppository | - |
dc.subject.keywordAuthor | Anti-tumor activity | - |
dc.identifier.url | https://kiss.kstudy.com/thesis/thesis-view.asp?key=2730462 | - |
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