A Novel Clotrimazole-loaded Suppository with Effective Anti-tumor Activity
- Authors
- Xuan, Jing Ji; Kim, Jong Tae; Oh, Dong Hoon; Lee, Won Seok; Lee, Jong Sook; Rhee, Jong Dal; Yong, Chul Soon; Woo, Jong Soo; Choi, Han-Gon
- Issue Date
- Oct-2008
- Publisher
- 한국약제학회
- Keywords
- Clotrimazole; Suppository; Anti-tumor activity
- Citation
- 약제학회지, v.38, no.5, pp.289 - 293
- Indexed
- KCI
- Journal Title
- 약제학회지
- Volume
- 38
- Number
- 5
- Start Page
- 289
- End Page
- 293
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42153
- ISSN
- 2093-5552
- Abstract
- To develop a poloxamer-based solid suppository with poloxamer and polyethylene glycol mixtures, the melting point of various formulations composed of P 188 and propylene glycol were investigated. The dissolution and antitumor activity of clotrimazole delivered by the poloxamer-based suppository were performed. The poloxamer mixtures composed of P 188 and propylene glycol were homogeneous phases. P 188 greatly affected the melting point of poloxamer mixtures. In particular, the poloxamer mixture [P 188/propylene glycol(70/30%)] with the melting point of about was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, the ratio of P 188/propylene glycol greatly affected the dissolution rates of clotrimazole from poloxamer-based suppository. It gave the more effective anti-tumor activity than conventional PEG-based suppository due to fast dissolution. Thus, the clotrimazole-Ioaded poloxamer-based solid suppository was an effective rectal dosage form with anti-tumor activity.
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