Fabrication of Terazocin-Loaded Poly(D,L-lactide) Microspheres by an Ultrasonic Spray Drying Method and Their Release Behaviors
DC Field | Value | Language |
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dc.contributor.author | An, Guk-Hwan | - |
dc.contributor.author | Kim, Min-Jung | - |
dc.contributor.author | Lee, Hak-Jong | - |
dc.contributor.author | Park, Sang-Soo | - |
dc.contributor.author | Cho, Yong Woo | - |
dc.contributor.author | Park, Kinam | - |
dc.contributor.author | Choa, Yong-Ho | - |
dc.date.accessioned | 2021-06-23T17:05:00Z | - |
dc.date.available | 2021-06-23T17:05:00Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42172 | - |
dc.description.abstract | Terazocin should be frequently administered for a long period time for the treatment of benign prostatic hyperplasia which is one of the most common diseases in elderly men. Controlled delivery of terazocin using polymer microspheres has a great potential to solve the problem. In this study, terazocin-incorporated poly(D,L-lactide) (PDLLA) microspheres were fabricated by a novel ultrasonic spray drying (USD) method, which is a rapid one-step process. The approximate diameters of microspheres were in a range of between 0.3 and 3 mu m. SEM confirmed that the microspheres had a spherical shape and narrow size distribution. FT-IR spectroscopy demonstrated that the incorporated terazocin remained intact after the USD process. The microspheres showed a fast initial burst release of terazocin within nine hours, followed by a slow but steady release for 49 days, suggesting that these microspheres are highly promising for controlled drug delivery. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | American Scientific Publishers | - |
dc.title | Fabrication of Terazocin-Loaded Poly(D,L-lactide) Microspheres by an Ultrasonic Spray Drying Method and Their Release Behaviors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Yong Woo | - |
dc.contributor.affiliatedAuthor | Choa, Yong-Ho | - |
dc.identifier.doi | 10.1166/jnn.2008.1138 | - |
dc.identifier.scopusid | 2-s2.0-58149235169 | - |
dc.identifier.wosid | 000261390500047 | - |
dc.identifier.bibliographicCitation | Journal of Nanoscience and Nanotechnology, v.8, no.10, pp.5139 - 5142 | - |
dc.relation.isPartOf | Journal of Nanoscience and Nanotechnology | - |
dc.citation.title | Journal of Nanoscience and Nanotechnology | - |
dc.citation.volume | 8 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 5139 | - |
dc.citation.endPage | 5142 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | DEVICES | - |
dc.subject.keywordAuthor | Utrasonic Spray Drying | - |
dc.subject.keywordAuthor | Microspheres | - |
dc.subject.keywordAuthor | Drug Delivery System | - |
dc.subject.keywordAuthor | Terazocin | - |
dc.subject.keywordAuthor | Poly(D,L-lactide) | - |
dc.identifier.url | https://www.ingentaconnect.com/content/asp/jnn/2008/00000008/00000010/art00047 | - |
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