Fabrication of Terazocin-Loaded Poly(D,L-lactide) Microspheres by an Ultrasonic Spray Drying Method and Their Release Behaviors
- Authors
- An, Guk-Hwan; Kim, Min-Jung; Lee, Hak-Jong; Park, Sang-Soo; Cho, Yong Woo; Park, Kinam; Choa, Yong-Ho
- Issue Date
- Oct-2008
- Publisher
- American Scientific Publishers
- Keywords
- Utrasonic Spray Drying; Microspheres; Drug Delivery System; Terazocin; Poly(D,L-lactide)
- Citation
- Journal of Nanoscience and Nanotechnology, v.8, no.10, pp.5139 - 5142
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Nanoscience and Nanotechnology
- Volume
- 8
- Number
- 10
- Start Page
- 5139
- End Page
- 5142
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42172
- DOI
- 10.1166/jnn.2008.1138
- ISSN
- 1533-4880
- Abstract
- Terazocin should be frequently administered for a long period time for the treatment of benign prostatic hyperplasia which is one of the most common diseases in elderly men. Controlled delivery of terazocin using polymer microspheres has a great potential to solve the problem. In this study, terazocin-incorporated poly(D,L-lactide) (PDLLA) microspheres were fabricated by a novel ultrasonic spray drying (USD) method, which is a rapid one-step process. The approximate diameters of microspheres were in a range of between 0.3 and 3 mu m. SEM confirmed that the microspheres had a spherical shape and narrow size distribution. FT-IR spectroscopy demonstrated that the incorporated terazocin remained intact after the USD process. The microspheres showed a fast initial burst release of terazocin within nine hours, followed by a slow but steady release for 49 days, suggesting that these microspheres are highly promising for controlled drug delivery.
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