Identification of Glutathione Conjugates of 1-Bromopentane and its Hepatotoxicity in Female BALB/c Mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Kyu | - |
dc.contributor.author | Lee, Dong Ju | - |
dc.contributor.author | Yoo, Hye Hyun | - |
dc.contributor.author | Kim, Ju Hyun | - |
dc.contributor.author | Seo, Young Nun | - |
dc.contributor.author | Shin, Sil | - |
dc.contributor.author | Choi, Jae Ho | - |
dc.contributor.author | Jeon, Tae Won | - |
dc.contributor.author | Kang, Mi Jeong | - |
dc.contributor.author | Jeong, Tae Cheon | - |
dc.date.accessioned | 2021-06-23T17:05:15Z | - |
dc.date.available | 2021-06-23T17:05:15Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/42181 | - |
dc.description.abstract | Halogenated organic compounds, such as 1-bromopentane (1-BPT), are used as cleaning agents, synthesis agents, or extraction solvents in the workplace. In the present study, glutathione (GSH) conjugation and hepatotoxicity induced by 1-BPT were investigated in female BALB/c mice. S-Bromopentyl GSH, S-bromopentyl cysteine, and mono-hydroxypentyl mercapturic acid were identified in liver by liquid chromatography-electrospray ionization tandem mass spectrometry. Oral treatment of mice with 1-BPT at 1500 mg/kg produced maximum GSH conjugates at 6 h after treatment. For hepatotoxicity tests, the animals were treated orally with 1-BPT at 375, 750, or 1500 mg/kg in corn oil once for a dose response study or at 1500 mg/kg for 6, 12, 24, or 48 h for a time course study. 1-BPT dose-dependently increased serum activity of ALT and AST and decreased hepatic GSH levels, peaking at 6 and 12 h after treatment. 1-BPT (750 and 1500 mg/kg) also significantly increased the hepatic content of malondialdehyde. Thus, 1-BPT could cause hepatotoxicity and depletion of GSH content by forming GSH conjugates, presenting a toxicity mechanism and potential biomarkers for low molecular weight haloalkanes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한약학회 | - |
dc.title | Identification of Glutathione Conjugates of 1-Bromopentane and its Hepatotoxicity in Female BALB/c Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoo, Hye Hyun | - |
dc.identifier.doi | 10.1007/s12272-001-2112-3 | - |
dc.identifier.scopusid | 2-s2.0-55149124042 | - |
dc.identifier.wosid | 000260302300013 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, v.31, no.10, pp.1317 - 1323 | - |
dc.relation.isPartOf | Archives of Pharmacal Research | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.volume | 31 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1317 | - |
dc.citation.endPage | 1323 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001286580 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | TANDEM MASS-SPECTROMETRY | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | 1,2-DIBROMOPROPANE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | ACIDS | - |
dc.subject.keywordAuthor | 1-Bromopentane | - |
dc.subject.keywordAuthor | Glutathione | - |
dc.subject.keywordAuthor | Conjugate structure | - |
dc.subject.keywordAuthor | Hepatotoxicity | - |
dc.subject.keywordAuthor | In vivo | - |
dc.subject.keywordAuthor | Mice | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12272-001-2112-3 | - |
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