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1-furan-2-yl-3-pyridin-2-yl-propenone inhibits the invasion and migration of HT1080 human fibrosarcoma cells through the inhibition of proMMP-2 activation and down regulation of MMP-9 and MT1-MMP
- Authors
- Park, Byung Chul; Thapa, Dinesh; Lee, Yoon-Seok; Kwak, Mi-Kyoung; Lee, Eung-Seok; Choi, Han Gon; Yong, Chul Soon; Kim, Jung-Ae
- Issue Date
- Jul-2007
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- 1-furan-2-yl-3-pyridin-2-yl-propenone; MMP-2; MMP-9; MT1-MMP; TIMP
- Citation
- EUROPEAN JOURNAL OF PHARMACOLOGY, v.567, no.3, pp.193 - 197
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF PHARMACOLOGY
- Volume
- 567
- Number
- 3
- Start Page
- 193
- End Page
- 197
- ISSN
- 0014-2999
- Abstract
- Matrix rnetalloproteinases (MMPs) play important roles in solid tumor invasion and migration. In this study, we showed that 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) dose-dependently inhibited HT1080 cell invasion and migration, and decreased NIMP-2 and MMP-9 activities. Furtherniore. FPP-3 reduced MMP-2 expression at protein and inRNA levels, and suppressed 12-0-tetradecanoylphorbol-13-acetate (TPA)enhanced expression of MTl-MMP without changing tissue inhibitors of rnetalloproteinase (TIMP)-2 level. FPP-3 also suppressed TPA-induced increases in MMP-9 protein and rnRNA levels, but did not alter TIMP-1 level. Our results suggest that FFP-3 may be a valuable anti-invasive drug candidate for cancer therapy by suppressing MMP-2, MMP-9, and MT1-MMP. (C) 2007 Elsevier B.V. All rights reserved.
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Related Researcher
- Choi, Han Gon
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)