Inhibitory effects of asiatic acid on 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice
- Authors
- Park, Byung Chul; Paek, Seung-Hwan; Lee, Yoon-Seok; Kim, Seung-Joo; Lee, Eung-Seok; Choi, Han Gon; Yong, Chul Soon; Kim, Jung-Ae
- Issue Date
- Jan-2007
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- asiatic acid; nitric oxide (NO); cyclooxygenase-2 (COX-2); 12-O-tetradecanoylphorbol 13-acetate (TPA); carcinogenesis
- Citation
- BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.30, no.1, pp.176 - 179
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Volume
- 30
- Number
- 1
- Start Page
- 176
- End Page
- 179
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/43929
- DOI
- 10.1248/bpb.30.176
- ISSN
- 0918-6158
- Abstract
- Asiatic acid, a pentacyclic triterpene, has been reported to induce apoptosis of various human cancer cells. In the present study, we assessed the anti-tumor promoting effect of asiatic acid against 12-O-tetradecanoylphorbol 13-acetate (TPA)-mediated skin tumorigenesis in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated ICR mice. Topical application of asiatic acid prior to each application of TPA resulted in a significant reduction in skin tumor formation. We also found that pre-application of asiatic acid alleviated TPA-induced [H-3]thymidine incorporation, which is a conventional marker for skin tumor promotion. In addition, asiatic acid inhibited the TPA-induced generation of nitric oxide (NO) and expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), which are known to play important roles in tumor growth, especially in the promotion stage. In addition, topical application of aminoguanidine (AG), a selective iNOS inhibitor, and N-G-nitro-L-arginine-methyl ester (NAME), another iNOS inhibitor, 30 min prior to TPA treatment significantly inhibited the TPA-induced COX-2 expression. These results suggest that asiatic acid may exert anti-tumorigenesis through inhibitory actions in NO and COX-2 signals.
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