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Microfluidic immunochip based on electrical detection system for cancer biomarker

Authors
Maeng, J.-H.Ko, Y.-J.Ahn, Y.Lee, S.-H.Cho, N.-G.Hwang, S.Y.
Issue Date
Oct-2007
Publisher
Chemical and Biological Microsystems Society
Keywords
Biomarker; Immuno-gold silver staining; Microbead; Microfilter
Citation
Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007, pp.503 - 505
Indexed
OTHER
Journal Title
Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Start Page
503
End Page
505
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/44241
ISSN
0000-0000
Abstract
We have developed and characterized a novel microbiochip which can simultaneously detect three cancer biomarkers by using microbeads, gold nanoparticles and silver enhancer. The integrated microbiochip that includes a Pt electrode to measure an electrical signal and a microfilter to fix the microbeads was fabricated. We adopted a filtration method using microbeads to immobilize antibody and an immuno-gold silver staining (IGSS) method to amplify electrical signals. Cancer biomarkers, Į-fetoprotein (AFP), carcinoembryonic antigen (CEA) and prostate-specific antigen (PSA), were successfully assayed by a sandwich immunoassay with this system. © 2007 CBMS.
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COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY > DEPARTMENT OF MOLECULAR & LIFE SCIENCE > 1. Journal Articles
COLLEGE OF ENGINEERING SCIENCES > DEPARTMENT OF MECHANICAL ENGINEERING > 1. Journal Articles

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ERICA 공학대학 (DEPARTMENT OF MECHANICAL ENGINEERING)
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