Fabrication of bio-composite drug delivery system using rapid prototyping technology
- Authors
- Chu, Won-Shik; Kim, Sung-Geun; Kim, Hyung-Jung; Lee, Caroline S.; Ahn, Sung-Hoon
- Issue Date
- Dec-2006
- Publisher
- Trans Tech Publications Ltd
- Keywords
- Bio-composite; Biodegradable; Drug delivery system (DDS); Rapid prototyping
- Citation
- Key Engineering Materials, v.342-343, pp 497 - 500
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- Key Engineering Materials
- Volume
- 342-343
- Start Page
- 497
- End Page
- 500
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/44331
- DOI
- 10.4028/www.scientific.net/KEM.342-343.497
- ISSN
- 1013-9826
1662-9795
- Abstract
- The rapid prototyping (RP) technology has advanced in various fields such as verification of design, and functional test. Recently, researchers have studied bio-materials to fabricate functional bio-RP parts. In this research, a nano composite deposition system (NCDS) was developed to fabricate three-dimensional functional parts for bio-applications. In the hybrid process, the material removal process by mechanical micro machining and/or the deposition process are combined. NCDS uses biocompatible or biodegradable polymer resin as matrix and various bio-ceramics to form bio-composite materials. To test drug release rate in vivo environment, two different types of drug delivery system (DDS) were fabricated using the bio-composite materials. 1) Container type DOS used poly(DL-lactide-co-glycolide acid)(50:50) and 5-fluorouracil as the drug composite while polycaprolactone(PCL) served as the container of the drug. 2) Scaffold type DDS formed porous microstructure with poly(DL-lactide-co-glycolide acid)(50:50) and 5-fluorouracil composite. The effect of geometry of the DDS on release rate of drug is under investigation.
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