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An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius
- Authors
- Yoo, Hye Hyun; Park, Jeong Hill; Kwon, Sung Won
- Issue Date
- Nov-2006
- Publisher
- Japan Society for Bioscience Biotechnology and Agrochemistry/Nippon Nogeikagaku Kai
- Keywords
- Carthamus tinctorius; tracheloside; anti-estrogenic activity; Ishikawa cell; bioassay-linked HPLC-ELSD
- Citation
- Bioscience, Biotechnology and Biochemistry, v.70, no.11, pp 2783 - 2785
- Pages
- 3
- Indexed
- SCOPUS
- Journal Title
- Bioscience, Biotechnology and Biochemistry
- Volume
- 70
- Number
- 11
- Start Page
- 2783
- End Page
- 2785
- ISSN
- 0916-8451
1347-6947
- Abstract
- The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC50 value of 0.31 mu g/ml, a level of inhibition comparable to that of tamoxifen (IC50 = 0.43 mu g/ml).
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Related Researcher
- Yoo, Hye Hyun
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)