Trials of novel C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylori infection in human subjects
DC Field | Value | Language |
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dc.contributor.author | Yong, Chul Soon | - |
dc.contributor.author | Kim, Yong-Il | - |
dc.contributor.author | Park, San-Man | - |
dc.contributor.author | Kwon, Rham | - |
dc.contributor.author | Han, Hong-Hee | - |
dc.contributor.author | Park, Jung Gil | - |
dc.contributor.author | Yang, Chan-Yoo | - |
dc.contributor.author | Kim, Jung-Ae | - |
dc.contributor.author | Yoo, Bong-Kyu | - |
dc.contributor.author | Rhee, Jong-Dal | - |
dc.contributor.author | Choi, Han-Gon | - |
dc.date.accessioned | 2021-06-23T21:06:32Z | - |
dc.date.available | 2021-06-23T21:06:32Z | - |
dc.date.created | 2021-01-21 | - |
dc.date.issued | 2006-10 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/44664 | - |
dc.description.abstract | To develop a C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylon infection, the C-13-urea-containing capsules were prepared with various additives such as polyethylene glycol, microcrystalline cellulose, sodium lauryl sulfate and citric acid. Their dissolution test and C-13-urea Breath Test in human volunteers were then performed. Polyethylene glycol increased the initial dissolution rates of urea and difference delta C-13 values from C-13-urea, while microcrystalline cellulose and sodium lauryl sulfate decreased them. Irrespective of addition of citric acid, the compositions with polyethylene glycol showed higher values from C-13-urea compared to a commercial 76 mg C-13-urea-containing capsule due to higher initial dissolution rate. The capsules with 38 Mg C-13-urea and 1.9 mg polyethylene glycol, which showed higher Helicobacter pylori-positive value of about 8 parts per thousand at 10 min, improved the sensitivity of C-13-urea in human volunteers. Thus, the C-13-urea-containing capsule with polyethylene glycol would be a more economical and sensitive preparation for diagnosis of Helicobacter pylori infection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Trials of novel C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylori infection in human subjects | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Han-Gon | - |
dc.identifier.doi | 10.1007/BF02973909 | - |
dc.identifier.scopusid | 2-s2.0-33751312231 | - |
dc.identifier.wosid | 000241675200011 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.29, no.10, pp.879 - 883 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 29 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 879 | - |
dc.citation.endPage | 883 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001087101 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | C-13-UREA BREATH TEST | - |
dc.subject.keywordPlus | SOLID DISPERSION | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | PHENYTOIN | - |
dc.subject.keywordPlus | TABLET | - |
dc.subject.keywordPlus | TESTS | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | urea | - |
dc.subject.keywordAuthor | polyethylene glycol | - |
dc.subject.keywordAuthor | dissolution | - |
dc.subject.keywordAuthor | 13C-urea breath test | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2FBF02973909 | - |
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