Trials of novel C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylori infection in human subjects
- Authors
- Yong, Chul Soon; Kim, Yong-Il; Park, San-Man; Kwon, Rham; Han, Hong-Hee; Park, Jung Gil; Yang, Chan-Yoo; Kim, Jung-Ae; Yoo, Bong-Kyu; Rhee, Jong-Dal; Choi, Han-Gon
- Issue Date
- Oct-2006
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Helicobacter pylori; urea; polyethylene glycol; dissolution; 13C-urea breath test
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.29, no.10, pp.879 - 883
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 29
- Number
- 10
- Start Page
- 879
- End Page
- 883
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/44664
- DOI
- 10.1007/BF02973909
- ISSN
- 0253-6269
- Abstract
- To develop a C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylon infection, the C-13-urea-containing capsules were prepared with various additives such as polyethylene glycol, microcrystalline cellulose, sodium lauryl sulfate and citric acid. Their dissolution test and C-13-urea Breath Test in human volunteers were then performed. Polyethylene glycol increased the initial dissolution rates of urea and difference delta C-13 values from C-13-urea, while microcrystalline cellulose and sodium lauryl sulfate decreased them. Irrespective of addition of citric acid, the compositions with polyethylene glycol showed higher values from C-13-urea compared to a commercial 76 mg C-13-urea-containing capsule due to higher initial dissolution rate. The capsules with 38 Mg C-13-urea and 1.9 mg polyethylene glycol, which showed higher Helicobacter pylori-positive value of about 8 parts per thousand at 10 min, improved the sensitivity of C-13-urea in human volunteers. Thus, the C-13-urea-containing capsule with polyethylene glycol would be a more economical and sensitive preparation for diagnosis of Helicobacter pylori infection.
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