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Trials of novel C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylori infection in human subjects

Authors
Yong, Chul SoonKim, Yong-IlPark, San-ManKwon, RhamHan, Hong-HeePark, Jung GilYang, Chan-YooKim, Jung-AeYoo, Bong-KyuRhee, Jong-DalChoi, Han-Gon
Issue Date
Oct-2006
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
Helicobacter pylori; urea; polyethylene glycol; dissolution; 13C-urea breath test
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.29, no.10, pp.879 - 883
Indexed
SCIE
SCOPUS
KCI
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
29
Number
10
Start Page
879
End Page
883
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/44664
DOI
10.1007/BF02973909
ISSN
0253-6269
Abstract
To develop a C-13-urea-containing capsule for more economic and sensitive diagnosis of Helicobacter pylon infection, the C-13-urea-containing capsules were prepared with various additives such as polyethylene glycol, microcrystalline cellulose, sodium lauryl sulfate and citric acid. Their dissolution test and C-13-urea Breath Test in human volunteers were then performed. Polyethylene glycol increased the initial dissolution rates of urea and difference delta C-13 values from C-13-urea, while microcrystalline cellulose and sodium lauryl sulfate decreased them. Irrespective of addition of citric acid, the compositions with polyethylene glycol showed higher values from C-13-urea compared to a commercial 76 mg C-13-urea-containing capsule due to higher initial dissolution rate. The capsules with 38 Mg C-13-urea and 1.9 mg polyethylene glycol, which showed higher Helicobacter pylori-positive value of about 8 parts per thousand at 10 min, improved the sensitivity of C-13-urea in human volunteers. Thus, the C-13-urea-containing capsule with polyethylene glycol would be a more economical and sensitive preparation for diagnosis of Helicobacter pylori infection.
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