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Estrogenic activity of furanocoumarins isolated from Angelica dahurica
- Authors
- Piao, Xiang Lan; Yoo, Hye Hyun; Kim, Hyun Young; Kang, Tak Lim; Hwang, Gwi Seo; Park, Jeong Hill
- Issue Date
- Sep-2006
- Publisher
- 대한약학회
- Keywords
- Angelica dahurica; Umbelliferae; furanocoumarin; estrogenic activity
- Citation
- Archives of Pharmacal Research, v.29, no.9, pp.741 - 745
- Indexed
- SCOPUS
KCI
- Journal Title
- Archives of Pharmacal Research
- Volume
- 29
- Number
- 9
- Start Page
- 741
- End Page
- 745
- ISSN
- 0253-6269
- Abstract
- In our efforts to discover novel phytoestrogens to treat menopausal symptoms, eleven furanocoumarins were isolated from Angelica dahurica and tested for their estrogenic activity on the Ishikawa cell line. Among the compounds tested, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin showed strong abilities to induce alkaline phosphatase (AP) with EC50 values of 1.1 and 0.8 mu g/mL, respectively, whereas the other nine furanocoumarins were weakly or only slightly active.
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Related Researcher
- Yoo, Hye Hyun
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)