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The cytotoxic saponin from heat-processed Achyranthes fauriei roots
- Authors
- Yoo, Hye Hyun; Kwon, Sung Won; Park, Jeong Hill
- Issue Date
- May-2006
- Publisher
- Pharmaceutical Society of Japan
- Keywords
- Achyranthes fauriei; Amaranthaceae; cytotoxic activity; bioassay-linked HPLC-ELSD; chikusetsusaponin IVa
- Citation
- Biological and Pharmaceutical Bulletin, v.29, no.5, pp.1053 - 1055
- Indexed
- SCOPUS
- Journal Title
- Biological and Pharmaceutical Bulletin
- Volume
- 29
- Number
- 5
- Start Page
- 1053
- End Page
- 1055
- ISSN
- 0918-6158
- Abstract
- An extract of heat-processed Achyranthes fauriei roots showed more potent cytotoxic activity against human hepatoma SK-Hep-1 cells than that of the crude plant. Employing a bioassay-linked HPLC-ELSD (high performance liquid chromatography-evaporative light scattering detector) method, followed by silica gel column chromatography, a cytotoxic triterpenoid saponin, chikusetsusaponin IVa was isolated. It is contributive to the increased cytotoxic activity of the heat-processed. The amount of chikusetsusaponin IVa from the roots of Achyranthes fauriei was significantly increased after heat-processing.
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Related Researcher
- Yoo, Hye Hyun
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)