로라제팜을 함유한 Poly(D,L-lactic acid) 마이크로스피어 개발Development of Poly(D,L-lactic acid) Microspheres Containing Lorazepam
- Other Titles
- Development of Poly(D,L-lactic acid) Microspheres Containing Lorazepam
- Authors
- 최한곤; 유봉규; 이종달; 김정애; 권태협; 우종수; 용철순
- Issue Date
- Jun-2006
- Publisher
- 한국약제학회
- Keywords
- Lorazepam; Poly(D,L-lactic acid); Microspheres; Injectable delivery system
- Citation
- Journal of Pharmaceutical Investigation, v.36, no.3, pp.175 - 184
- Indexed
- KCI
- Journal Title
- Journal of Pharmaceutical Investigation
- Volume
- 36
- Number
- 3
- Start Page
- 175
- End Page
- 184
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/45223
- DOI
- 10.4333/KPS.2006.36.3.175
- ISSN
- 2093-5552
- Abstract
- Poly(D,L-lacic acid)(PLA) microshperes containing loazepam were prepared by a solvent-emulsion evaporation method and their release patterns were investigated in vitro. Various batches of microspheres with different size and drug content were obtained by changing the ratio of lorazepam to PLA, PLA concentration in the dispersed phase and stirring rate. Rod-like lorazepam crystals on microsphere surface, which were released rapidly and could act as a loading dose, were observed with increasing drug content. The release rate was increased with increase in drug contents and decrease in the molecular weight of PLA. The release rate of lorazepam for long-acting injectable delivery system in vitro, which would aid in Predicting in vivo release Profile, could be controlled by properly optimizing various factors affecting characteristics of microspheres.
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