Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Reduction of Oncogene Expression in Cancer Cells Using siRNA Delivery Systems

Authors
Kim, Eun-Joong (Kim, Young-BongChoi, Han-GonShim, Chang-Koo (Oh, Yu-Kyoung
Issue Date
Oct-2005
Publisher
한국약제학회
Keywords
siRNA; Delivery systems; Polyethylenimine; Lipofectamine; Cervical cancer cells
Citation
한국약제학회지, v.35, no.5, pp.343 - 348
Indexed
KCI
Journal Title
한국약제학회지
Volume
35
Number
5
Start Page
343
End Page
348
URI
https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/45704
DOI
10.4333/KPS.2005.35.5.343
ISSN
2093-5552
Abstract
Recently, siRNA has been emerging as new therapeutic agents for various diseases such as cancers and infectious diseases. However, the evaluation for delivery systems for siRNA has not been fully done. In this study, we designed and delivered siRNA of oncogenic E6 and E7 proteins to several cell lines and tested the delivery efficiencies of various cationic nonviral delivery vectors. Of cationic delivery systems tested in this study, lipid-based Lipofectamine revealed higher delivery efficiency of siRNA to cervical cancer cell line, SiHa, compared to other delivery systems. Notably, the polyethylenimine, which showed the comparable delivery efficiencies in plasmid DNA, did not show significant delivery of siRNA in cervical cancer cells. These results indicate that the mechanisms involved in siRNA delivery might be different from those in plasmid DNA delivery, and that cationic lipid-based delivery vehicles deliver siRNA with higher efficiency to intracellular target sites.
Files in This Item
Go to Link
Appears in
Collections
COLLEGE OF PHARMACY > DEPARTMENT OF PHARMACY > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choi, Han Gon photo

Choi, Han Gon
COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)
Read more

Altmetrics

Total Views & Downloads

BROWSE