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Peptide-cleaving catalyst selective for peptide deformylase
- Authors
- Chae, Pil-seok; Kim, Myoungsoon; Jeung, Chul-seung; Lee,Seongdu; Park, Hwangseo; Lee, Sangyoub; Suh, Junghun
- Issue Date
- Mar-2005
- Publisher
- American Chemical Society
- Citation
- Journal of the American Chemical Society, v.127, no.8, pp.2396 - 2397
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of the American Chemical Society
- Volume
- 127
- Number
- 8
- Start Page
- 2396
- End Page
- 2397
- ISSN
- 0002-7863
- Abstract
- A peptide-cleaving catalyst selective for peptide deformylase (PDF) was obtained from a library containing about 15000 catalyst candidates. The catalyst cleaved the polypeptide backbone of PDF at Gln(152)-Arg(153). Docking simulations suggested multiple modes of interactions in the complex formed between the catalyst and PDF. Copyright © 2005 American Chemical Society.
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Related Researcher
- Chae, Pil Seok
- ERICA 공학대학 (DEPARTMENT OF BIONANO ENGINEERING)