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HPLC method for the pharmacokinetics study of acemetacin in human plasma

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dc.contributor.authorBan, E-
dc.contributor.authorCho, JH-
dc.contributor.authorJang, DJ-
dc.contributor.authorPiao, XL-
dc.contributor.authorKim, JK-
dc.contributor.authorJi, JP-
dc.contributor.authorKim, CK-
dc.date.accessioned2021-06-24T00:37:55Z-
dc.date.available2021-06-24T00:37:55Z-
dc.date.created2021-01-21-
dc.date.issued2005-02-
dc.identifier.issn1082-6076-
dc.identifier.urihttps://scholarworks.bwise.kr/erica/handle/2021.sw.erica/46513-
dc.description.abstractA reproducible and specific high performance liquid chromatography (HPLC) method was developed to quantity plasma levels of acemetacin and its metabolite, indometacin in order to conduct a pharmacokinetics study. Plasma samples were prepared by liquid-liquid extraction using ethyl acetate.- Extracted samples were analyzed on a reverse-phase C-18 column with a mobile phase consisting of 20mM phosphate buffer (pH 2.9) and acetonitrile (60:40, v/v) and UV detection at 254nm. Using this method, the phannacokinctics study was carried out on eight volunteers after a single oral administration.-
dc.language영어-
dc.language.isoen-
dc.publisherTAYLOR & FRANCIS INC-
dc.titleHPLC method for the pharmacokinetics study of acemetacin in human plasma-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, JK-
dc.identifier.doi10.1081/JLC-200058377-
dc.identifier.scopusid2-s2.0-20844444002-
dc.identifier.wosid000230093000014-
dc.identifier.bibliographicCitationJOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, v.28, no.10, pp.1593 - 1604-
dc.relation.isPartOfJOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES-
dc.citation.titleJOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES-
dc.citation.volume28-
dc.citation.number10-
dc.citation.startPage1593-
dc.citation.endPage1604-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemical Research Methods-
dc.relation.journalWebOfScienceCategoryChemistry, Analytical-
dc.subject.keywordPlusLIQUID-CHROMATOGRAPHY-
dc.subject.keywordPlusINDOMETHACIN-
dc.subject.keywordAuthoracemetacin-
dc.subject.keywordAuthorindometacin-
dc.subject.keywordAuthorhigh performance liquid chromatography (HPLC)-
dc.identifier.urlhttps://www.tandfonline.com/doi/full/10.1081/JLC-200058377-
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