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HPLC method for the pharmacokinetics study of acemetacin in human plasma
- Issue Date
- Feb-2005
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- acemetacin; indometacin; high performance liquid chromatography (HPLC)
- Citation
- JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, v.28, no.10, pp.1593 - 1604
- Indexed
- SCIE
SCOPUS
- Volume
- 28
- Number
- 10
- Start Page
- 1593
- End Page
- 1604
- ISSN
- 1082-6076
- Abstract
- A reproducible and specific high performance liquid chromatography (HPLC) method was developed to quantity plasma levels of acemetacin and its metabolite, indometacin in order to conduct a pharmacokinetics study. Plasma samples were prepared by liquid-liquid extraction using ethyl acetate.- Extracted samples were analyzed on a reverse-phase C-18 column with a mobile phase consisting of 20mM phosphate buffer (pH 2.9) and acetonitrile (60:40, v/v) and UV detection at 254nm. Using this method, the phannacokinctics study was carried out on eight volunteers after a single oral administration.
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Related Researcher
- Kim, Jin-Ki
- COLLEGE OF PHARMACY (DEPARTMENT OF PHARMACY)