Immunosuppressive activity of cepacidine A, a novel antifungal antibiotic produced by Pseudomonas cepacia
- Authors
- Lee, CH; Suh, JW; Cho, YH
- Issue Date
- Oct-1999
- Publisher
- SPRINGER-VERLAG SINGAPORE PTE LTD
- Keywords
- antifungal antibiotic; cepacidine A; immunosuppressive activity
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.9, no.5, pp.672 - 674
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 9
- Number
- 5
- Start Page
- 672
- End Page
- 674
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/46990
- ISSN
- 1017-7825
- Abstract
- Cepacidine A was first identified as a novel antifungal antibiotic which was isolated from the culture broth of Pseudomonas cepacia AF2001. It showed a potent in vitro antifungal activity against various pathogenic fungi, but did not show any activity against bacteria. Recently, the immunosuppressive action of cepacidine A was discovered using an in vitro screening system involving inhibition of the proliferation of murine lymphocytes stimulated by 2 mitogens, and also by in. vivo mouse models involving inhibition of delayed type hypersensitivity and SRBC hemagglutination. Cepacidine A showed a significant activity of cellular immunosuppression (ED50) at concentration levels of 1-3 mg/kg, i.p.. Unfortunately, the delayed toxicity at a dose of above 3 mg/kg i.p. was apparent.
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