Changes of nitric oxide synthase activity and free methylarginines contents in regenerating rat liver after partial hepatectomy
- Authors
- Lee, Young Jin; Nam, Suk Woo; Seo, Dong Wan; Ahn, Seong Hoon; Ko, Young Kwon; Sung, Dae Suk; Han, Jeung Whan; Hong, Sung Youl; Lee, Hyang Woo
- Issue Date
- Jun-1997
- Publisher
- 대한약학회
- Keywords
- N-G-monomethyl-L-arginine; N-G; N-G-dimethylarginine; nitric oxide; partial hepatectomy
- Citation
- Archives of Pharmacal Research, v.20, no.3, pp.239 - 246
- Indexed
- SCIE
SCOPUS
- Journal Title
- Archives of Pharmacal Research
- Volume
- 20
- Number
- 3
- Start Page
- 239
- End Page
- 246
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/47039
- DOI
- 10.1007/BF02976151
- ISSN
- 0253-6269
- Abstract
- In the present study, liver regeneration rate (%) was increased up to 70% 3 days after partial hepatectomy (PH). Nitric oxide synthase (NOS) activity in liver tissue as well as serum nitrite/nitrate content had no timed response, revealing no significant difference between sham-operated and partially hepatectomized rat liver. Contents of free methylarginines in liver tissue were increased biphasically in a time-dependent manner after PH. However, those in serum did not exhibit the same patterns as in liver. Taken together, the results suggest that N-G-monomethyl-L-arginine (MMA) and N-G, N-G-dimethylarginine (DMA) play a role in inhibiting nitric oxide (NO) synthesis in regenerating rat liver because the increase of their contents was synchronized with NOS expression.
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