HisCoM-GGI: Software for Hierarchical structural component analysis of gene-gene interactionsopen access
- Authors
- Choi, Sung kyoung; Lee, Sungyoung; Park, Taesung
- Issue Date
- Dec-2018
- Publisher
- 한국유전체학회
- Keywords
- gene-gene interactions; generalized structured component analysis; genome-wide association study; ridge regression
- Citation
- Genomics & Informatics, v.16, no.4, pp.1 - 3
- Indexed
- KCI
- Journal Title
- Genomics & Informatics
- Volume
- 16
- Number
- 4
- Start Page
- 1
- End Page
- 3
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/5047
- DOI
- 10.5808/GI.2018.16.4.e38
- ISSN
- 1598-866X
- Abstract
- Gene-gene interaction (GGI) analysis is known to play an important role in explaining missing heritability. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in a case-control design. In this study, we developed “Hierarchical structural CoMponent analysis of Gene-Gene Interactions” (HisCoM-GGI) software for GGI analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various types of genomic data and supports data management and multithreading to improve the efficiency of genome-wide association study data analysis. We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.
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