Palladium nanoparticle-decorated 2-D graphene oxide for effective photodynamic and photothermal therapy of prostate solid tumors
- Authors
- Thapa, Raj Kumar; Soe, Zar Chi; Ou, Wenquan; Poudel, Kishwor; Jeong, Jee-Heon; Jin, Sung Giu; Ku, Sae Kwang; Choi, Han-Gon; Lee, You Mie; Yong, Chul Soon; Kim, Jong Oh
- Issue Date
- Sep-2018
- Publisher
- ELSEVIER
- Keywords
- Graphene oxide; Palladium nanoparticles; Photothermal therapy; Prostate cancer; Reactive oxygen species
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.169, pp.429 - 437
- Indexed
- SCIE
SCOPUS
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 169
- Start Page
- 429
- End Page
- 437
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/5639
- DOI
- 10.1016/j.colsurfb.2018.05.051
- ISSN
- 0927-7765
- Abstract
- Intratumoral injection of nanoparticles is a viable alternative for treating solid tumors. In this study, we used intratumorally-injected palladium nanoparticle (Pd NP)-decorated graphene oxide (GO) (GO-Pd NPs) for the treatment of solid prostate tumors. GO was synthesized using the modified Hummer's method and GO-Pd NPs were prepared using the one pot synthesis method. Studies on physicochemical characterization and in vitro/in vivo anticancer properties were performed using GO-Pd NPs. Successful preparation of GO-Pd NPs was confirmed by transmission electron microscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Compared to GO or Pd NPs alone, GO-Pd NPs showed higher cytotoxic effects in prostate cancer 3 (PC3) cells. Irradiation of treated cells with near infrared (NIR) laser considerably enhanced apoptosis induced by synergistic photothermal effect and reactive oxygen species (ROS) generation. Intratumorally-injected GO-Pd NPs showed promising in vivo localized distribution, photothermal ablation, and anti-tumor effects in the PC3 xenograft mouse model. Furthermore, the minimal organ toxicity of GO-Pd NPs was an added advantage. Hence, GO-Pd NPs could be a potential formulation for localized treatment of prostate solid tumors.
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