Responsive Assembly of Upconversion Nanoparticles for pH-Activated and Near-Infrared-Triggered Photodynamic Therapy of Deep Tumors
- Authors
- Li, Fangyuan; Du, Yang; Liu, Jianan; Sun, Heng; Wang, Jin; Li, Ruiqing; Kim, Dokyoon; Hyeon, Taeghwan; Ling, Daishun
- Issue Date
- Aug-2018
- Publisher
- WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Keywords
- nanoassembly; photodynamic therapy; pH-responsive; theranostics; upconversion nanoparticle
- Citation
- Advanced Materials, v.30, no.35, pp.1 - 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Advanced Materials
- Volume
- 30
- Number
- 35
- Start Page
- 1
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/erica/handle/2021.sw.erica/5676
- DOI
- 10.1002/adma.201802808
- ISSN
- 0935-9648
- Abstract
- Upconversion nanoparticle (UCNP)-mediated photodynamic therapy has shown great effectiveness in increasing the tissue-penetration depth of light to combat deep-seated tumors. However, the inevitable phototoxicity to normal tissues resulting from the lack of tumor selectivity remains as a major challenge. Here, the development of tumor-pH-sensitive photodynamic nanoagents (PPNs) comprised of self-assembled photosensitizers grafted pH-responsive polymeric ligands and UCNPs is reported. Under neutral pH conditions, photosensitizers aggregated in the PPNs are self-quenched; however, upon entry into a tumor microenvironment with lower pH, the PPNs not only exhibit enhanced tumor-cell internalization due to charge reversal but also are further disassembled into well-dispersed nanoparticles in the endo/lysosomes of tumor cells, enabling the efficient activation of photosensitizers. The results demonstrate the attractive properties of both UCNP-mediated deep-tissue penetration of light and high therapeutic selectivity in vitro and in vivo.
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